WARNING: This blog includes descriptions of self-harming
behaviors, please take that into consideration before you
continue reading and especially if you choose to leave a comment.
Here’s an AI generated
definition of treatment resistant depression:
Treatment-resistant depression (TRD) is the lack of
response to at least two different, adequate antidepressant treatments for
major depressive disorder, meaning the symptoms don't improve or only partially
improve after taking the medications for sufficient time and dosage. While
there isn't a universally agreed-upon official definition, the condition is
identified by the failure to achieve adequate improvement with standard
treatments and requires further investigation to find an effective course of
action.
I’ve had a major
depressive disorder since I was roughly 22 years old. I’ve had treatment resistant depression since roughly
2006 when I had a 12-treatment course of ECT (electro-convulsive therapy), generally
known as “shock therapy.” I had 2 weeks of ECT on a Monday-Wednesday-Friday
schedule, then 2 weeks on a Tuesday-Thursday schedule, finally I had 2 weeks of
weekly treatments on Wednesdays.
By the 5th week
Mark had to carry me from the car into our house after treatments because my
head hurt literally beyond description, I was weak, I had unending
vomiting on treatment days, and I could barely sip water and eat 6 saltine
crackers throughout the course of the treatment days.
During the last 2 weeks of
treatments, I attended the wedding of one of my best friends and I remember
none of it. Thank God we have pictures so at least I could see the lovely bride
and groom, their flowers, and my other friends in attendance.
In early October 2023 my
depression symptoms were worsening. I spent weekly sessions with my
psychiatrist trying an addition of another antidepressant, reported no improvement,
that med was discontinued and another antidepressant was added, yet again I
reported no improvement, and my symptoms were still worsening. Finally, I did some
online research and found oral Ketamine treatment for treatment resistant
depression. Costs were all out of pocket, I had to provide medical information,
have an online interview with the prescriber for medical clearance, meet with a
“guide”, and document my intentions pre-treatment and what I got “out of the
medication session” to discuss with my guide.
I had a 6-treatment weekly
course of 800mcg (I’m not sure how they measure the doses, it could be micrograms,
milligrams, I don’t really know) but after week 4 I started feeling a shit
ton less depressed and that continued for about 18 months. Which brings me
to late summer/early fall 2025.
My shrink and I have gone
back and forth over the years discussing if I may have bipolar disorder, which
as of my last appointment with him on August 4, 2025, I’m not diagnosed with. I
agree with that…there are times when my depression was so severe, I would have
given anything for a smidge of hypomania, which never happened.
By mid-September this year
I started feeling overwhelmed, anxious, and once again worsening depression. I
believed I was an independent woman who ought to be able to manage my emotions
without any help or support outside of my therapist and my shrink. I said
nothing to anyone except for them about how I was spiraling down, down, down.
I couldn’t wait for my
psychiatrist to tinker with my meds or take weekly doses of oral Ketamine
through the previous online organization I had previously used and received
significant relief. I needed help NOW.
On September 21st
I found a local provider of IV Ketamine, 6 total sessions on a Monday-Wednesday-Friday
schedule for 2 weeks starting October 13th. They use an app where I
complete daily mood ratings, journal, have access to an online community, and
PHQ-9 depression assessments.
This is my entry for Friday
October 10th:
I had
a breakdown. I slammed my hands against the bathroom counter while sitting down in front of the shower and slammed
my head against it a few times. Then I laid down
on the bath mat and cried. I took the scissors and cut off my hair. No idea what I was doing, I just kept cutting
and cutting until 80 percent of it was gone. I can’t
look in a mirror to see my ugly face and what I’m sure is my ugly hair. I am useless, I am a burden. I can’t stand
myself.
I had my first IV Ketamine
session on Monday, October 13th. As of today (10/23/25) I’ve had 5
sessions. I was originally scheduled for 6 sessions, but after talking with my
provider she recommended 8 sessions, so my last medication session is now
Wednesday, October 29th. My anticipated return to work date on a
part time schedule is Tuesday, November 4th. I’m receiving short
term disability, 60% of my regular salary, which is enough to get us through.
My “mood trend” scores
have gone from 3 on a 1/10 scale on 10/05/25 to 7/10 on 10/23/25 which is a
clinically significant increase in mood. I have another week and a half before
this part of my medication journey concludes. We’ll see where I go from here.